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July 1, 1998AJP Heart and Circulatory Physiology

Melatonin improves cerebral circulation security margin in rats

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Why the study?

Does melatonin improve the cerebrovascular dilatory reserve and shift the lower limit of cerebral blood flow autoregulation in adult male Wistar rats?

Population

Adult male Wistar rats (n=45; 9 rats per group)

Comparison

Melatonin infusions of 60, 600, or 60,000 ng/kg/h vs Vehicle infusion or no infusion

Design

Preclinical

Authors

OROlivier RégrignyPDPhilippe DelagrangeESElizabeth Scalbert

Discussion

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Overview

No immediate clinical implications; extends preclinical data on melatonin and leaves open human translation.

Structured PICO

Does melatonin improve the cerebrovascular dilatory reserve and shift the lower limit of cerebral blood flow autoregulation in adult male Wistar rats?

P
Population
Adult male Wistar rats (n=45; 9 rats per group)
I
Intervention
Melatonin infusions of 60, 600, or 60,000 ng/kg/h
C
Comparator
Vehicle infusion or no infusion
O
Outcome
Lower limit of cerebral blood flow autoregulation (evaluated from the fall in cerebral blood flow following hypotensive hemorrhage) and cerebrovasodilatory reserve (evaluated from the increase in cerebral blood flow under hypercapnia)surrogate

Melatonin improves the cerebrovascular security margin in rats by shifting the lower limit of cerebral blood flow autoregulation, suggesting a potential role in diminishing the risk of hypoperfusion-induced cerebral ischemia.

Cite This Study

Régrigny et al. (1998) studied this question.

synapsesocial.com/papers/6a70989184cc45bb7bdfcba4https://doi.org/10.1152/ajpheart.1998.275.1.h139
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Also Consider

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  4. 4Diurnal variation in incidence of stroke: Oxfordshire community stroke project.1992 · 165 citations
  5. 5Nocturnal Melatonin Excretion is Decreased in Patients With Migraine Without Aura Attacks Associated With Menses1995 · 103 citations