Three novel 2,3-diaryl indone derivatives, ascomindones A−C ( 1 − 3 ), and two new isobenzofuran derivatives, ascomfurans A ( 4 ) and B ( 5 ), together with four know compounds ( 6 − 9 ) were isolated from the culture of a mangrove-derived fungus Ascomycota sp. SK2YWS-L. Their structures were elucidated on the interpretation of spectroscopic data. 1 and 4 were further constructed by analysis of X-ray diffraction. Antioxidant properties based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical scavenging activities and the ferric reducing ability power (FRAP) of the new compounds were assayed. All of them exhibited significant effects, of which 1 showed more potent activity than ascorbic acid in scavenging DPPH radical with IC 50 value of 18.1 μ M.
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Tan et al. (2016) studied this question.