What question did this study set out to answer?

To determine the spatiotemporal expression of the intermediate filament nestin and its regulatory mechanisms during glial scar formation following central nervous system injury.

October 15, 1995The Journal of Cell BiologyOpen Access

Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury.

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Authors

JFJonas FrisénKarolinska Institutet CJClas B. JohanssonKarolinska University Hospital CTCarina TörökKarolinska University Hospital

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Implication

Animal study reveals rapid and prolonged nestin induction following central nervous system injury in rodents, suggesting stem-like cell migration participates in glial scar formation.

Key Points

To determine the spatiotemporal expression of the intermediate filament nestin and its regulatory mechanisms during glial scar formation following central nervous system injury.
Evaluated spinal cord injury and optic nerve crush models in rats and wild-type mice, tracking tissue responses for up to 13 months.
Analyzed gene regulatory dynamics after traumatic injury using transgenic mice expressing a lacZ reporter under the control of the nestin promoter.
Nestin expression was induced in reactive astrocytes within 48 hours both at the lesion site and along degenerating tracts, persisting for at least 13 months, with parallel induction kinetics in the crushed optic nerve.
Nestin- and lacZ-positive cells emerged near the spinal cord central canal within 48 hours post-injury and located progressively farther outward over time, consistent with injury-induced cell proliferation and migration.

Cite This Study

Frisén et al. (1995) studied this question.

synapsesocial.com/papers/6a709a8bf44fa9f079de45eb https://doi.org/10.1083/jcb.131.2.453

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Implication

Animal study reveals rapid and prolonged nestin induction following central nervous system injury in rodents, suggesting stem-like cell migration participates in glial scar formation.

Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury.

Discussion

Member takes

Implication

Key Points

Cite This Study

Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury.

Discussion

Member takes

Implication

Key Points

Cite This Study

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