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September 2, 2015Journal of Cardiovascular and Thoracic ResearchOpen Access

Correlation of Serum Levels of Vitronectin, Malondialdehyde and Hs-CRP With Disease Severity in Coronary Artery Disease

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Why the study?

Do serum levels of Vitronectin, malondialdehyde, and hs-CRP correlate with disease severity in patients with coronary artery disease?

Population

250 subjects including 200 patients with angiographically diagnosed coronary artery disease and 50 CAD-free…

Comparison

Angiographically diagnosed coronary artery disease vs Normal coronary angiography (CAD-free controls)

Design

Case-control

Authors

AYAlireza YaghoubiMGMorteza GhojazadehSASakhavat Abolhasani

Discussion

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Overview

Hypothesis-generating for VN, MDA, and hs-CRP as CAD severity markers; prospective validation required before clinical adoption.

Structured PICO

Do serum levels of Vitronectin, malondialdehyde, and hs-CRP correlate with disease severity in patients with coronary artery disease?

P
Population
250 subjects including 200 patients with angiographically diagnosed coronary artery disease (CAD) (50 with non-significant CAD, 50 with single vessel disease, 50 with double vessel disease, and 50 with triple vessel disease) and 50 CAD-free subjects as a control group. Mean age 58 years for CAD patients, 56.5 years for controls. Excluded: history of any heart disease, lung disorder, liver dysfunction, renal disease and cancer.
I
Intervention
Angiographically diagnosed coronary artery disease (CAD)
C
Comparator
Normal coronary angiography (CAD-free controls)
O
Outcome
Correlation of serum levels of Vitronectin (VN), malondialdehyde (MDA) and high-sensitivity C-reactive protein (hs-CRP) with the severity of coronary artery disease (CAD)surrogate

Serum levels of Vitronectin, malondialdehyde, and hs-CRP are significantly elevated in patients with coronary artery disease and correlate with angiographic disease severity, suggesting their potential utility as diagnostic and monitoring biomarkers.

Cite This Study

Yaghoubi et al. (2015) studied this question.

synapsesocial.com/papers/6a709ab3ac440176ef29438dhttps://doi.org/10.15171/jcvtr.2015.24
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Also Consider

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