Why the study?
Does intravenous sodium chloride infusion suppress plasma renin activity independently of volume expansion in sodium chloride-depleted rats?
Does intravenous sodium chloride infusion suppress plasma renin activity independently of volume expansion in sodium chloride-depleted rats?
Acute suppression of plasma renin activity by saline infusion in rats is dependent on chloride rather than volume expansion per se, and is not related to changes in renal PGE2 synthesis.
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Suggests chloride-specific renin suppression beyond volume in rats; leaves open translation to human cardiorenal physiology or practice.
Lorenz et al. (1986) studied this question.
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