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Decreased muscle potassium and increased sodium in rats made magnesium deficient suggested the possibility of increased aldosterone secretion. Muscle and plasma electrolytes and secretion of aldosterone and corticosterone in magnesium-deficient rats were compared with the same values in pair-fed controls. Aldosterone secretion by the magnesium-depleted animals was increased, while corticosterone secretion was decreased. Altered steroid secretion adequately explains the altered sodium and potassium metabolism. (Endocrinology80: 969, 1967)
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Ginn et al. (1967) studied this question.
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