What question did this study set out to answer?

To develop and characterize specific antisera and cDNA probes directed against noncollagenous proteins of the bone matrix in humans and animal models.

January 1, 1995Acta Orthopaedica ScandinavicaOpen Access

Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins

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Authors

LFLarry W. FisherNational Institute of Dental and Craniofacial Research JSJohn T. StubbsHoward University MYMarian F. YoungNational Institutes of Health

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Implication

Laboratory investigation characterizes antisera and cDNA probes against noncollagenous bone matrix proteins across species, highlighting new molecular tools for studying skeletal biology.

Key Points

To develop and characterize specific antisera and cDNA probes directed against noncollagenous proteins of the bone matrix in humans and animal models.
Isolated and purified noncollagenous matrix proteins from human and selected animal bone tissues to generate specific polyclonal antisera.
Synthesized and screened complementary DNA (cDNA) probes corresponding to targeted bone matrix proteins for cross-species evaluation.
Generated cross-reactive antisera capable of specifically identifying and characterizing noncollagenous proteins in human and animal skeletal matrices qualitatively.
Produced cDNA probes suitable for investigating gene expression and structural homology of noncollagenous bone matrix components.

Cite This Study

Fisher et al. (1995) studied this question.

synapsesocial.com/papers/6a709c3cb27f158178276fe2 https://doi.org/10.3109/17453679509157649

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Implication

Laboratory investigation characterizes antisera and cDNA probes against noncollagenous bone matrix proteins across species, highlighting new molecular tools for studying skeletal biology.

Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins

Discussion

Member takes

Implication

Key Points

Cite This Study

Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins

Discussion

Member takes

Implication

Key Points

Cite This Study

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