What question did this study set out to answer?

To review the mechanisms by which P2 nucleotide receptors modulate vascular and inflammatory cells during atherosclerosis, and to evaluate their potential as therapeutic targets.

February 1, 2002British Journal of PharmacologyOpen Access

P2 receptors: new potential players in atherosclerosis

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To review the mechanisms by which P2 nucleotide receptors modulate vascular and inflammatory cells during atherosclerosis, and to evaluate their potential as therapeutic targets.
Narrative synthesis of molecular and cellular pathways controlled by P2 receptors across endothelial cells, smooth muscle cells, leukocytes, and platelets.
Evaluation of findings from clinical trials investigating platelet ADP receptor antagonists for vascular event prevention.
P2 receptors mediate vital cellular events in plaque formation, including leukocyte chemotaxis, cytokine secretion, nitric oxide generation, and smooth muscle cell proliferation.
Platelet ADP receptor antagonism demonstrates proven clinical efficacy in reducing the incidence of vascular accidents in patients with atherosclerosis.
Targeting nucleotide-mediated signaling cascades presents novel opportunities for drug design and therapeutic intervention in atheroma development.

Design

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Authors

FVFrancesco Di VirgilioLinköping University ASAnna SoliniGeneral / Preventive / Lipids

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Implication

P2 receptor modulation merits targeted drug development in atherosclerosis; leaves open clinical benefit pending prospective trials.

Cite This Study

Virgilio et al. (2002) studied this question.

synapsesocial.com/papers/6a709c86b27f158178277010 https://doi.org/10.1038/sj.bjp.0704524

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P2 receptors: new potential players in atherosclerosis

Key Points

Discussion

Implication

Cite This Study

P2 receptors: new potential players in atherosclerosis

Key Points

Discussion

Implication

Cite This Study

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