Why the study?
Familial Hypercholesterolaemia is common yet underdiagnosed and undertreated, though primary care can be a valuable asset for opportunistic detection and management.
Do targeted detection and management strategies improve the identification of familial hypercholesterolaemia and reduce LDL-c levels in primary care?
Do targeted detection and management strategies improve the identification of familial hypercholesterolaemia and reduce LDL-c levels in primary care?
Various primary care strategies, including electronic extraction tools and alert systems, can improve the detection of familial hypercholesterolaemia and significantly reduce LDL-c levels, though standardized diagnostic criteria are needed.
Primary care strategies for FH detection show variable uptake; leaves open which approaches best improve outcomes in prospective studies.
Background Familial Hypercholesterolaemia (FH) is a genetic condition characterised by a lifelong elevation of low-density lipoprotein cholesterol (LDL-c). FH is one of the most common genetic diseases, with an estimated global prevalence of 1 in 250 individuals. However, it is both underdiagnosed and undertreated. Primary care can be a valuable asset for the opportunistic detection and management of FH. Aim To examine the employed strategies for improving the detection and management of FH in a primary care setting. Method Six electronic databases (PubMed, The Cochrane Central Register of Controlled Trials, Web of Science, CINAHL, ProQuest, and Scopus) were searched from May – June 2022 for papers published in English following Arksey and O’Malley’s six-stage scoping review process. Results The initial search identified 1401 articles and a total of 30 studies were included in this review. A diverse range of methods have been studied for improving identification of FH. Three studies examined reduction in patient LDL-c levels from management in primary care. Two thirds of the studies with primary care management had a significant reduction in patient LDL-c levels. Conclusion The lack of consistency across the diagnostic criteria and the low number of studies addressing the reduction of patient LDL-c levels are major features of this review. Further research should be conducted to evaluate the effectiveness of the approaches for improving the detection and management of adult patients with FH in a primary care setting.
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Khan et al. (2023) studied this question.
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