Population
Rabbit atrial myocytes
Comparison
Spermine (300 nM to 3 microM) vs Absence of spermine / presence of intracellular…
Design
Preclinical
Authors
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May modulate atrial KACh gating in animal models; leaves open polyamine roles in human inward rectification or arrhythmias.
Spermine and other polyamines may act as unidentified intracellular gating factors for strong inward rectifiers such as KACh and IK1 channels in atrial myocytes.
Yamada et al. (1995) studied this question.
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