Population
Guinea-pig ventricular cells
Comparison
Internal application of millimolar… vs Absence of internal Mg2+ or Na+
Design
Preclinical
Authors
Loading...
Supports Mg2+/Na+ block as mechanism of KATP rectification in ventricular myocytes; leaves open translation to human ischemia or arrhythmia.
Intracellular Mg2+ and Na+ cause voltage-dependent block of ATP-sensitive K+ channels in guinea-pig ventricular cells, accounting for their inward rectification.
Horie et al. (1987) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: