What question did this study set out to answer?

To resolve whether glucose is imported directly by neurons or routed through astrocytes via lactate conversion during brain activation.

April 23, 2015Nature CommunicationsOpen Access

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

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Authors

ILIben LundgaardLund University BLBaoman LiUniversity of Rochester Medical Center LXLulu XieWenzhou University

Discussion

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Implication

In vivo imaging study demonstrates preferential neuronal glucose uptake during brain activation in awake mice, indicating neurons directly fuel activity-dependent metabolism.

Key Points

To resolve whether glucose is imported directly by neurons or routed through astrocytes via lactate conversion during brain activation.
Conducted in vivo two-photon microscopy in awake behaving mice and anesthetized mice using a near-infrared 2-deoxyglucose analogue (2DG-IR).
Measured cell-type-specific glucose tracer uptake during sensory stimulation.
Quantified hexokinase enrichment in mouse and human cerebral cortex to assess neuronal versus astrocytic glycolytic capacity.
Neurons directly and preferentially absorbed 2DG-IR over astrocytes in awake behaving mice, a pattern abolished under anesthesia.
Sensory stimulation triggered an immediate, sharp surge in neuronal glucose uptake without a detectable rise in astrocytic uptake.
Hexokinase showed marked enrichment in cortical neurons relative to astrocytes in both mouse and human brain tissue.

Cite This Study

Lundgaard et al. (2015) studied this question.

synapsesocial.com/papers/6a709de4febe604dd7096307 https://doi.org/10.1038/ncomms7807

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April 23, 2015Nature CommunicationsOpen Access

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

View Full Paper

Ask AI

Bookmark

Authors

ILIben LundgaardLund University BLBaoman LiUniversity of Rochester Medical Center LXLulu XieWenzhou University

Discussion

Member takes

Implication

In vivo imaging study demonstrates preferential neuronal glucose uptake during brain activation in awake mice, indicating neurons directly fuel activity-dependent metabolism.

Key Points

To resolve whether glucose is imported directly by neurons or routed through astrocytes via lactate conversion during brain activation.
Conducted in vivo two-photon microscopy in awake behaving mice and anesthetized mice using a near-infrared 2-deoxyglucose analogue (2DG-IR).
Measured cell-type-specific glucose tracer uptake during sensory stimulation.
Quantified hexokinase enrichment in mouse and human cerebral cortex to assess neuronal versus astrocytic glycolytic capacity.
Neurons directly and preferentially absorbed 2DG-IR over astrocytes in awake behaving mice, a pattern abolished under anesthesia.
Sensory stimulation triggered an immediate, sharp surge in neuronal glucose uptake without a detectable rise in astrocytic uptake.
Hexokinase showed marked enrichment in cortical neurons relative to astrocytes in both mouse and human brain tissue.

Cite This Study

Lundgaard et al. (2015) studied this question.

synapsesocial.com/papers/6a709de4febe604dd7096307 https://doi.org/10.1038/ncomms7807

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