Key result
Boronate-agarose affinity yields ~2.3-point lower glycated hemoglobin than ion-exchange chromatography in azotemic nondiabetic patients.
Observational
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We evaluated the effect of azotemia on results for glycated hemoglobin as measured by a boronate-agarose affinity method and an ion-exchange chromatographic procedure with saline preincubation and found a good correlation. However, values for glycated hemoglobin in samples from nondiabetic patients with various degrees of azotemia were consistently higher with the ion-exchange column procedure (mean, 8.5%) than with the boronate affinity method (mean, 6.2%). The latter method may thus be preferred for monitoring glycated hemoglobin in diabetic patients with impaired renal function.
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Scott et al. (1984) conducted an observational in Azotemia. Boronate-agarose affinity method vs. Ion-exchange chromatographic procedure with saline preincubation was evaluated on Glycated hemoglobin values (%). The boronate-agarose affinity method yielded lower mean glycated hemoglobin values than ion-exchange chromatography in nondiabetic patients with azotemia (6.2% vs 8.5%).
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