Why the study?
Does paroxetine pretreatment alter the pharmacokinetics and pharmacodynamics of nebivolol in healthy volunteers?
Does paroxetine pretreatment alter the pharmacokinetics and pharmacodynamics of nebivolol in healthy volunteers?
Paroxetine significantly increases systemic exposure to nebivolol due to CYP2D6 inhibition, though this did not significantly alter resting vital signs in healthy volunteers.
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Paroxetine coadministration may raise nebivolol exposure; leaves open need for dose adjustment or monitoring in patients.
Briciu et al. (2014) studied this question.
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