Phospholamban phosphorylation, particularly at the Thr17 residue, is crucial for mechanical and intracellular Ca2+ recovery during myocardial stunning and protects against Ca2+ overload-induced mechanical abnormalities.
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PLN Thr17 phosphorylation may protect against stunning in ischemia-reperfusion; leaves open whether targeting it improves human outcomes.
Valverde et al. (2006) studied this question.
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