Osteopontin, a Coordinator of Host Defense System: a Cytokine or an Extracellular Adhesive Protein?

Microbiology and ImmunologyVolume 41, Issue 9 p. 641-648 MinireviewFree Access Osteopontin, a Coordinator of Host Defense System: a Cytokine or an Extracellular Adhesive Protein? Toshimitsu Uede, Corresponding Author Toshimitsu Uede Section of Immunopathogenesis, Institute of Immunological Science, Hokkaido University, Sapporo, Hokkaido, 060 JapanAddress correspondence to Dr. Toshimitsu Uede, Section of Immunopathogenesis, Institute of Immunological Science, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Hokkaido 060, Japan.Search for more papers by this authorYohko Katagiri, Yohko Katagiri Section of Immunopathogenesis, Institute of Immunological Science, Hokkaido University, Sapporo, Hokkaido, 060 JapanSearch for more papers by this authorJunko Lizuka, Junko Lizuka Section of Immunopathogenesis, Institute of Immunological Science, Hokkaido University, Sapporo, Hokkaido, 060 JapanSearch for more papers by this authorMasaaki Murakami, Masaaki Murakami Section of Immunopathogenesis, Institute of Immunological Science, Hokkaido University, Sapporo, Hokkaido, 060 JapanSearch for more papers by this author Toshimitsu Uede, Corresponding Author Toshimitsu Uede Section of Immunopathogenesis, Institute of Immunological Science, Hokkaido University, Sapporo, Hokkaido, 060 JapanAddress correspondence to Dr. Toshimitsu Uede, Section of Immunopathogenesis, Institute of Immunological Science, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Hokkaido 060, Japan.Search for more papers by this authorYohko Katagiri, Yohko Katagiri Section of Immunopathogenesis, Institute of Immunological Science, Hokkaido University, Sapporo, Hokkaido, 060 JapanSearch for more papers by this authorJunko Lizuka, Junko Lizuka Section of Immunopathogenesis, Institute of Immunological Science, Hokkaido University, Sapporo, Hokkaido, 060 JapanSearch for more papers by this authorMasaaki Murakami, Masaaki Murakami Section of Immunopathogenesis, Institute of Immunological Science, Hokkaido University, Sapporo, Hokkaido, 060 JapanSearch for more papers by this author First published: 14 November 2013 https://doi.org/10.1111/j.1348-0421.1997.tb01906.xCitations: 64AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abbreviations AII angiotensin II bFGF basic fibroblast growth factor CD44s standard isoform of CD44 CD44V variable isoform of CD44 CMEC cardial microvascular endothelial cell DN double negative Eta-1 early T lymphocyte activation-1 HA hyaluronate iNOS inducible nitric oxide synthase LPS lipopolysaccharide NO nitric oxide OPN osteopontin PDGF platelet-derived growth factor RGD arginine-glycine-aspartic acid RT Rickettsia tsutsugamushi; SMC smooth muscle cell TGF-β transforming growth factor-β. References 1Anderson, G., and Jennische, E. 1988. IGF-I immunoreactivity is expressed by regenerating renal tubular cells after ischemic injury in the rat. Acta Physiol. Scand. 132: 453– 457. Wiley Online LibraryPubMedWeb of Science®Google Scholar 2Aruffo, A., Stamenkovic, I., Melnick, M., Underhill, C.B., and Seed, B. 1990. CD44 is the principal cell surface receptor for hyaluronate. Cell 61: 1303– 1313. 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