Why the study?
Sleep is considered a key behavioral factor in atherosclerosis progression, with autonomic nervous function as a potential mechanism, motivating an examination of recent findings to understand the pathophysiological mechanisms.
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Design
Review
Sleep evaluation may refine CV risk stratification; leaves open whether autonomic dysfunction mediates atherosclerosis.
Behavioral and psychosocial factors related to development of cardiovascular disease have been gaining increased attention. Notably, sleep is considered to be one of the most important behavioral factors involved in progression of atherosclerosis and cardiovascular events, with autonomic nervous function a potential mechanism. Several studies have shown associations of sleep and autonomic dysfunction with major surrogate markers of atherosclerosis, such as carotid intima-media thickness and arterial stiffness. Endocrinological, immunological, oxidative, inflammatory, and metabolic responses, as well as endothelial dysfunction may mediate the effects of the autonomic nervous system. For this review, we examined recent findings related to sleep, autonomic nervous dysfunction, and atherosclerosis, with the aim of understanding the involved pathophysiological mechanisms.
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Kadoya et al. (2019) studied this question.
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