Phenylalanine hydroxylase has been obtained from rat liver in a form that is 85 to 95% pure. The enzyme exists as two electrophoretically distinguishable isozymes, each of which is capable of existing as a monomer (51,000 to 55,000 molecular weight), dimer (110,000), and tetramer (210,000). The dimers of each isozyme will dissociate to the monomeric forms by dilution of the enzyme or by increasing the temperature from 0 to 30°.
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Kaufman et al. (1970) studied this question.
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