May inform myocyte contractility mechanisms but should not alter practice; leaves open validation in multicellular or in vivo models.
The Frank-Starling mechanism is one of the most fundamental properties of cardiac muscle for exerting intrinsic control over contractile force on a beat to beat basis. According to this law, the systolic contractile force depends on the preceding diastolic blood loading. In other words stretching the ventricular muscle induces an increase in contractility. In multicellular preparations the mechanisms that underlie the length-force relationship in the myocardium have been the subject of considerable discussion and controversy.1-7
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D Garnier (1994) studied this question.
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