April 18, 2016Scientific ReportsOpen Access

EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice

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Why the study?

Does EGFR inhibition prevent hyperlipidemia-induced cardiac injury in mice?

Structured PICO

Does EGFR inhibition prevent hyperlipidemia-induced cardiac injury in mice?

Population

Wild type (WT) and apolipoprotein E (ApoE) knockout mice fed with high fat diet (HFD), and H9C2 cardiomyocytes stimulated with palmitic acid (PA)

Intervention

Small-molecule EGFR inhibitors (AG1478 and 542) and siRNA silencing

Outcome

Myocardial inflammation, fibrosis, apoptosis, and dysfunctionsurrogate

EGFR inhibition attenuates obesity-induced cardiac inflammatory injuries and apoptosis in experimental models, suggesting a potential therapeutic target for obesity-related cardiovascular diseases.

Discussion

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Implication

EGFR inhibition may attenuate hyperlipidemia-related cardiac injury; leaves open clinical translation pending human trials.

Cite This Study

Li et al. (2016) studied this question.

synapsesocial.com/papers/6a70a2b7b27f15817827728c https://doi.org/10.1038/srep24580

View Full Paper

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EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice

Structured PICO

Discussion

Implication

Cite This Study

EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider