Why the study?
Heart failure with supranormal left ventricular ejection fraction has distinct risk factors and pathogenesis associated with increased mortality, requiring separate identification for risk stratification and optimal treatment.
Heart failure with supra-normal left ventricular ejection fraction (>65%) should be recognized as a distinct phenotype due to its unique risk profile and high mortality.
HF patients with EF >65% may need closer monitoring; leaves open whether LVEF phenotypes require revision.
Currently, the main criterion for dividing patients with heart failure into phenotypes is left ventricular ejection fraction. Traditionally, patients with reduced, moderately reduced and preserved left ventricular ejection fraction are distinguished. However, the risk of death increases in patients with heart failure and ejection fraction >65%. Moreover, ejection fraction 70% is accompanied by mortality rate comparable to patients with ejection fraction 35—40%. Risk factors and pathogenesis of heart failure with preserved and supranormal left ventricular ejection fraction have some features that requires a separate identification of phenotype with heart failure with supranormal left ventricular ejection fraction for further risk stratification and searching for the most optimal treatment.
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Kachnov et al. (2023) studied this question.
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