Why the study?
Does mexiletine improve electrophysiologic abnormalities and clinical symptoms in a patient with paramyotonia congenita?
Population
A patient with paramyotonia congenita presenting with cold-induced hand and jaw stiffening, in the absence…
Design
Case_report
Authors
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May support mexiletine in paramyotonia congenita; hypothesis-generating and requires controlled confirmation before practice change.
Does mexiletine improve electrophysiologic abnormalities and clinical symptoms in a patient with paramyotonia congenita?
Mexiletine therapy can resolve electrophysiologic abnormalities and improve clinical symptoms in patients with paramyotonia congenita presenting without episodic weakness.
Jackson et al. (1994) studied this question.