What question did this study set out to answer?

To characterize functionally relevant conformational states of the voltage-dependent Na+ channel and their transitions.

Inactivation of Open and Closed Sodium Channels Determined Separately

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Randomized trial examines sodium channel transitions and conductance in nerve impulses, indicating functional dynamics.

To characterize functionally relevant conformational states of the voltage-dependent Na+ channel and their transitions.
Single-channel recording experiments conducted to observe Na+ channel function.
Measurement of conductance for ions associated with each channel state.
Determination of rate constants and their voltage dependence across transitions.
Identification of major conformational states of the Na+ channel.
Measurement of transition rates between these states under varying voltage conditions.
Establishment of ion conductance linked to each identified state.

Aldrich et al. (1983) studied this question.

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