What question did this study set out to answer?

To characterize the timing, magnitude, and antiviral efficacy of the earliest HIV-1-specific T-cell responses directed against the transmitted/founder virus during acute infection.

June 1, 2009The Journal of Experimental MedicineOpen Access

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

View Full Paper

Ask AI

Bookmark

Authors

NGNilu GoonetillekeUniversity of North Carolina at Chapel Hill MLMichael K. P. LiuImperial College London JSJesus F. Salazar-GonzalezNational Institutes of Health

Discussion

Member takes

Implication

Cohort study reveals rapid CD8 T-cell-mediated viral escape during early viral load decline in acute HIV-1 infection, indicating initial cellular immunity drives early viremia control.

Key Points

To characterize the timing, magnitude, and antiviral efficacy of the earliest HIV-1-specific T-cell responses directed against the transmitted/founder virus during acute infection.
Analyzed primary HIV-1-specific T-cell responses across the entire viral proteome in three acutely infected patients.
Identified genomic sites of positive selection using specialized algorithms combined with cellular assays to track viral escape mutations.
Employed kinetic analysis and mathematical modeling to quantify the rate of CD8 T-cell-mediated killing of infected cells over time.
CD8 T-cell killing of productively infected cells occurred earlier and at a substantially greater magnitude than previously estimated, contributing directly to the initial decline in plasma viremia.
Initial T-cell responses rapidly selected viral escape mutations and waned, being replaced by responses targeting more conserved or slowly escaping epitopes that help set the viral load set point.
Additional viral diversification accumulated independently of T-cell responses via neutralizing antibody selection in the envelope gene, reversions to consensus sequences, and linked bystander mutations.

Cite This Study

Goonetilleke et al. (2009) studied this question.

synapsesocial.com/papers/6a70a40835aa2c282ce1f6ff https://doi.org/10.1084/jem.20090365

View Full Paper

Ask AI

Bookmark

Implication

Cohort study reveals rapid CD8 T-cell-mediated viral escape during early viral load decline in acute HIV-1 infection, indicating initial cellular immunity drives early viremia control.

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

Discussion

Member takes

Implication

Key Points

Cite This Study

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider