Population
Intact rat hearts (fluo-4 AM-loaded)
Comparison
Global acidosis or low-flow global ischemia… vs Control conditions (baseline)
Design
Preclinical
Authors
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May link ischemia to alternans-driven proarrhythmia in myocytes; leaves open translation to human arrhythmia risk.
Global acidosis and ischemia modify intracellular calcium cycling in rat myocytes, increasing susceptibility to calcium transient and repolarization alternans at slower heart rates, which may underlie ischemia-induced proarrhythmia.
Kapur et al. (2009) studied this question.
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