New conditions, full transfer: Using MgBr2/MeOH as an additive now provides essentially 100 % retention of configuration in the lithiation–borylation reaction, thus leading to tertiary boronic esters (or tertiary alcohols) with exceptionally high ee values in all cases—even with rather hindered substrates and more stabilized lithiated carbamates (see scheme; Cb=carbamate, pin=OCMe2CMe2O).
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Bagutski et al. (2010) studied this question.
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