Why the study?
Producing functional hERG channels is important for preventing drug toxicity in early drug discovery and developing techniques to gain structural insight into the channel.
Population
Different orthologous hosts including yeast, bacteria, insect, and human cell lines
Comparison
Methods for over-expressing mutated functional hERG across different hosts and engineered constructs
Design
Comparative laboratory study
Authors
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Having functional hERG channels available supports early drug toxicity screening; leaves open structural insights for safer therapeutics.
HEK cells provide an effective recombinant system for producing large quantities of functional hERG channels, enabling future structural and pharmacological toxicity studies.
Vasseur et al. (2019) studied this question.
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