January 1, 1992Journal of Veterinary Medical ScienceOpen Access

African Swine Fever Virus: Generation of Subpopulations with Altered Immunogenicity and Virulence Following Passage in Cell Cultures.

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Population

Vero cell cultures and susceptible pigs

Design

Preclinical

Authors

IPI. C. PanAnimal Health Research Institute

Discussion

Member takes

Implication

Cell culture passaging risks unstable ASFV vaccine candidates; leaves open reliable attenuation strategies for protective immunity in swine.

Structured PICO

Population

Vero cell cultures and susceptible pigs

Intervention

Passaging Tengani isolate of African swine fever virus (biologically cloned or uncloned) in Vero cell cultures

Outcome

Virulence, immunogenicity, and infectivity to pigs

Passaging African swine fever virus in cell cultures generates subpopulations with altered virulence and immunogenicity, complicating the development of attenuated vaccines.

Cite This Study

I. C. Pan (1992) studied this question.

synapsesocial.com/papers/6a70a7362fdcb5703edb6412 https://doi.org/10.1292/jvms.54.43

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Implication

Cell culture passaging risks unstable ASFV vaccine candidates; leaves open reliable attenuation strategies for protective immunity in swine.

African Swine Fever Virus: Generation of Subpopulations with Altered Immunogenicity and Virulence Following Passage in Cell Cultures.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

African Swine Fever Virus: Generation of Subpopulations with Altered Immunogenicity and Virulence Following Passage in Cell Cultures.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider