May 1, 1986Journal of VirologyOpen Access

Monoclonal antibodies of African swine fever virus: antigenic differences among field virus isolates and viruses passaged in cell culture

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Population

African swine fever virus particles, including 7 clones isolated from the spleen of a field-infected pig and…

Design

Preclinical

Authors

BGBlanca García‐BarrenoCentro de Investigación Biomédica en Red de Enfermedades Respiratorias ASAlberto SanzThe University of Melbourne MNMarisa NogalCentro de Biología Molecular Severo Ochoa

Discussion

Member takes

Implication

Antigenic diversity among African ASFV strains may hinder broad vaccine efficacy; leaves open serotype-specific immunization strategies for swine.

Structured PICO

Population

African swine fever virus particles, including 7 clones isolated from the spleen of a field-infected pig and 23 field isolates from Africa, Europe, and America, as well as cell-adapted virus passaged in Vero cells.

Intervention

Analysis of binding properties using a collection of monoclonal antibodies.

Outcome

Antigenic differences and binding properties of viral proteins (including p150, p27, p37, p14, and p12).

African swine fever virus exhibits significant antigenic variability, particularly among African isolates, suggesting a complex variety of serotypes.

Cite This Study

García‐Barreno et al. (1986) studied this question.

synapsesocial.com/papers/6a8143489fceb4fbd5e3e147 https://doi.org/10.1128/jvi.58.2.385-392.1986

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Implication

Antigenic diversity among African ASFV strains may hinder broad vaccine efficacy; leaves open serotype-specific immunization strategies for swine.

Monoclonal antibodies of African swine fever virus: antigenic differences among field virus isolates and viruses passaged in cell culture

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Monoclonal antibodies of African swine fever virus: antigenic differences among field virus isolates and viruses passaged in cell culture

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider