Neutralizing antibodies against African swine fever virus target different stages of infection, with anti-p72 and anti-p54 blocking attachment and anti-p30 blocking internalization.
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Stage-specific ASFV antibodies may guide vaccine antigen selection; leaves open in vivo efficacy and swine translation.
African swine fever virus induces in convalescent pigs antibodies that neutralized the virus before and after binding to susceptible cells, inhibiting both virus attachment and internalization. A further analysis of the neutralization mechanisms mediated by the different viral proteins showed that antibodies to proteins p72 and p54 are involved in the inhibition of a first step of the replication cycle related to virus attachment, while antibodies to protein p30 are implicated in the inhibition of virus internalization.
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Gómez‐Puertas et al. (1996) studied this question.
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