Neutralizing antibodies against African swine fever virus target different stages of infection, with anti-p72 and anti-p54 blocking attachment and anti-p30 blocking internalization.
African swine fever virus induces in convalescent pigs antibodies that neutralized the virus before and after binding to susceptible cells, inhibiting both virus attachment and internalization. A further analysis of the neutralization mechanisms mediated by the different viral proteins showed that antibodies to proteins p72 and p54 are involved in the inhibition of a first step of the replication cycle related to virus attachment, while antibodies to protein p30 are implicated in the inhibition of virus internalization.
Gómez‐Puertas et al. (Thu,) studied this question.