Dictyostelium myosin heavy chain kinase A regulates myosin localization during growth and development.

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Population

Dictyostelium cells

Comparison

MHCK A gene disruption and MHCK A overexpression vs Normal/wild-type Dictyostelium cells (implied)

Design

Preclinical

Authors

Discussion

Supports MHCK A as myosin regulator in Dictyostelium; leaves open extension to mammalian cardiovascular models.

Population

Dictyostelium cells

Intervention

MHCK A gene disruption (mhck A- cells) and MHCK A overexpression (MHCK A++ cells)

Comparator

Normal/wild-type Dictyostelium cells (implied)

Outcome

Cellular consequences including myosin localization, MHC kinase activity, myosin assembly, growth rates, and developmental progressionsurrogate

MHCK A functions in vivo as a protein kinase that regulates myosin II localization and assembly in Dictyostelium cells during growth and development.

Kolman et al. (1996) studied this question.

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