January 1, 2010BioMed Research InternationalOpen Access

Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice

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Population

MuRF1-KO mice

Comparison

MuRF1 inactivation and 10-day hindlimb suspension vs Wild-type mice (implied)

Design

Preclinical

Follow-up

10 days

Authors

SLSiegfried LabeitHeart Failure & Transplant CKChristine KohlMax Planck Institute of Psychiatry CWChristian WittUniversity of Vermont

Discussion

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Implication

May limit MuRF1 as an atrophy target due to functional costs in rodents; leaves open therapeutic translation to human disuse atrophy.

Structured PICO

Population

MuRF1-KO mice

Intervention

MuRF1 inactivation (knockout) and 10-day hindlimb suspension

Comparator

Wild-type mice (implied)

Outcome

Muscle atrophy responsesurrogate

MuRF1 plays a dual role in skeletal muscle, where its inactivation protects against unloading-induced atrophy but impairs muscle contractility by increasing fatigue and reducing twitch potentiation.

Cite This Study

Labeit et al. (2010) studied this question.

synapsesocial.com/papers/6a70a86eac440176ef295317 https://doi.org/10.1155/2010/693741

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Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider