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To determine the relationship between occupational low-to-moderate hexavalent chromium exposure and biomarkers of oxidative stress, genetic damage, and epigenetic alterations.

June 12, 2025Environmental ResearchOpen Access

Oxidative damage, genetic and epigenetic alterations in hexavalent chromium exposed workers - A cross-sectional study within the SafeChrom project

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To determine the relationship between occupational low-to-moderate hexavalent chromium exposure and biomarkers of oxidative stress, genetic damage, and epigenetic alterations.
Conducted a cross-sectional study within the SafeChrom project enrolling 113 hexavalent chromium (Cr(VI)) exposed workers across 14 companies and 72 unexposed controls.
Measured Cr(VI) in inhalable dust and total chromium in urine (U-Cr) and red blood cells (RBC-Cr).
Quantified biomarkers including urinary 8-OHdG, reticulocyte micronuclei, mitochondrial DNA copy number, relative telomere length, and DNA methylation of lung cancer-related genes (F2RL3, LINE-1, MGMT promoter, SEMA4B).
Exposed workers showed significantly higher levels of urinary 8-OHdG, longer telomere length, and elevated MGMT promoter methylation compared with controls in multivariate adjusted models.
Mitochondrial DNA copy number and reticulocyte micronucleus frequency were lower in exposed workers than in controls.
Telomere length was positively correlated with urinary chromium, while 8-OHdG and MGMT promoter methylation were positively correlated with red blood cell chromium levels.

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Implication

A cross-sectional study reveals oxidative damage and epigenetic alterations in hexavalent chromium exposed workers, indicating potential carcinogenic mechanisms at moderate exposure.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/6a70a8c7439bab0cabc34382 https://doi.org/10.1016/j.envres.2025.122123

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Implication

A cross-sectional study reveals oxidative damage and epigenetic alterations in hexavalent chromium exposed workers, indicating potential carcinogenic mechanisms at moderate exposure.

Oxidative damage, genetic and epigenetic alterations in hexavalent chromium exposed workers - A cross-sectional study within the SafeChrom project

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Discussion

Implication

Cite This Study

Oxidative damage, genetic and epigenetic alterations in hexavalent chromium exposed workers - A cross-sectional study within the SafeChrom project

Key Points

Discussion

Implication

Cite This Study

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