What question did this study set out to answer?

To determine whether experimental feline leukemia virus (FeLV) infection impairs the phagocytic function of polymorphonuclear leukocytes during and after active viremia.

January 1, 1986Cancer Investigation

Demonstration of Depressed Polymorphonuclear Leukocyte Function in Nonviremic FeLV-Infected Cats

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To determine whether experimental feline leukemia virus (FeLV) infection impairs the phagocytic function of polymorphonuclear leukocytes during and after active viremia.
Compared polymorphonuclear leukocytes isolated from healthy control cats and experimentally infected FeLV cats.
Measured phagocytic activity using a luminol-dependent chemiluminescent response assay at one week post-infection, during active viremia, and following clearance of viremia.
Polymorphonuclear leukocytes from infected cats displayed a marked reduction in phagocytic response within one week post-infection.
Leukocyte suppression persisted during active viremia and remained depressed even after the cessation of detectable viremia.

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Implication

Experimental study demonstrates persistent polymorphonuclear leukocyte dysfunction in FeLV-infected cats after cessation of viremia, suggesting subclinical immune suppression.

Cite This Study

Lafrado et al. (1986) studied this question.

synapsesocial.com/papers/6a70a8e75d37378ac1ddcb5c https://doi.org/10.3109/07357908609017509

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Implication

Experimental study demonstrates persistent polymorphonuclear leukocyte dysfunction in FeLV-infected cats after cessation of viremia, suggesting subclinical immune suppression.

Demonstration of Depressed Polymorphonuclear Leukocyte Function in Nonviremic FeLV-Infected Cats

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Discussion

Implication

Cite This Study

Demonstration of Depressed Polymorphonuclear Leukocyte Function in Nonviremic FeLV-Infected Cats

Key Points

Discussion

Implication

Cite This Study

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