What question did this study set out to answer?

Determine whether feline lymphocytic leukemia can be transmitted serially via cell-free passage and characterize the viral morphology and associated pathology.

June 1, 1969JNCI Journal of the National Cancer Institute

A Transmissible Virus-Induced Lymphocytic Leukemia of the Cat2

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Authors

CRC. G. RickardCornell University JPJohn E. PostConnecticut Agricultural Experiment Station FNFernando NoronhaUniversidade do Porto

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Implication

Experimental study demonstrates serial cell-free transmission of lymphocytic leukemia via type C viral particles in kittens, highlighting a viral etiology for feline hematologic cancers.

Key Points

Determine whether feline lymphocytic leukemia can be transmitted serially via cell-free passage and characterize the viral morphology and associated pathology.
Inoculated 68 kittens across 7 serial passages with cell-free filtrates derived from a spontaneous case of feline lymphocytic leukemia.
Evaluated gross pathology, tumor histology, and virus presence via 141 electron microscopic bone marrow biopsies performed in 68 cats.
Cultured neoplastic lymph nodes, thymus, and bone marrow tissues to assess in vitro production of infectious viral particles.
Leukemia was successfully transmitted to 56 of 68 inoculated kittens (82.4%), with latent periods ranging from 30 to 139 days (median 53 days).
Inoculated cats developed generalized lymphadenopathy, splenomegaly, and malignant lymphoma, showing 110-mμ type C retrovirus particles budding into intercellular spaces, predominantly in bone marrow.
Bone marrow electron microscopy yielded 34 positive biopsies across 18 cats and 107 negative biopsies across 50 cats, while 4 kittens additionally developed multiple co-occurring liposarcomas.

Cite This Study

Rickard et al. (1969) studied this question.

synapsesocial.com/papers/6a70c841a7fbea1e4408330b https://doi.org/10.1093/jnci/42.6.987

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Implication

Experimental study demonstrates serial cell-free transmission of lymphocytic leukemia via type C viral particles in kittens, highlighting a viral etiology for feline hematologic cancers.

A Transmissible Virus-Induced Lymphocytic Leukemia of the Cat2

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Implication

Key Points

Cite This Study

A Transmissible Virus-Induced Lymphocytic Leukemia of the Cat2

Discussion

Member takes

Implication

Key Points

Cite This Study

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