Why the study?
The pathogenesis of diabetic retinopathy is multifactorial and not fully understood, though aberrant levels of certain long non-coding RNAs are implicated in its development.
This review summarizes the role of lncRNAs in the pathogenesis of diabetic retinopathy, providing directions for future research.
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LncRNA dysregulation may drive DR progression; extends mechanistic insights but leaves open clinical translation.
Diabetic retinopathy (DR), which is known as a severe complication of type 2 diabetes mellitus, can cause varying degrees of damage to visual acuity. The pathogenesis of DR is multifactorial and not fully understood. Many previous research studies have revealed that an aberrant level of some long non-coding RNAs (lncRNAs) may accelerate the development of DR. These lncRNAs are regulatory factors and research related to them is always underway. In this review, we will update several types of lncRNAs based on the previous studies which are related to the development of DR and discuss its potential mechanisms of action and connections. Generally, the review will help us know more about lncRNAs and provide directions for future research related to DR.
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Huang et al. (2020) studied this question.
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