What question did this study set out to answer?

To determine whether heat stress enhances arterial baroreflex control of muscle sympathetic nerve activity by increasing burst gating sensitivity, burst area sensitivity, or both.

April 1, 2006The Journal of PhysiologyOpen Access

Heat stress enhances arterial baroreflex control of muscle sympathetic nerve activity via increased sensitivity of burst gating, not burst area, in humans

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Why the study?

Does whole-body heating enhance arterial baroreflex control of muscle sympathetic nerve activity in normotensive humans?

Population

10 normotensive subjects, mean age 32+/-2 years

Comparison

Whole-body heating vs Normothermic conditions

Design

Other

Authors

DKDaniel M. KellerUniversitätsklinikum Würzburg JCJian CuiElectrophysiology SDScott L. DavisBrigham Young University–Hawaii

Discussion

Member takes

Implication

May inform thermoregulatory sympathetic studies; hypothesis-generating and should not yet change practice.

Key Points

To determine whether heat stress enhances arterial baroreflex control of muscle sympathetic nerve activity by increasing burst gating sensitivity, burst area sensitivity, or both.
Measured peroneal muscle sympathetic nerve activity (MSNA) using microneurography in 10 normotensive subjects (mean ± s.e.m. age: 32 ± 2 years).
Compared 5-minute data windows between normothermic and whole-body heating conditions, calculating burst incidence and burst area across 3 mmHg diastolic blood pressure bins.
Whole-body heating significantly increased the slope relating burst incidence to diastolic blood pressure from -2.49 ± 0.38 (r² = 0.73 ± 0.06) to -4.69 ± 0.44 (r² = 0.84 ± 0.03; P < 0.05).
The slope relating burst area to diastolic blood pressure remained unchanged between normothermia (-1.13 ± 0.46; r² = 0.45 ± 0.09) and whole-body heating (-0.92 ± 0.29; r² = 0.41 ± 0.08; P = 0.50).

Structured PICO

Does whole-body heating enhance arterial baroreflex control of muscle sympathetic nerve activity in normotensive humans?

Population

10 normotensive subjects, mean age 32+/-2 years

Intervention

Whole-body heating

Comparator

Normothermic conditions

Outcome

Arterial baroreflex control of muscle sympathetic nerve activity (burst incidence and area per burst relative to diastolic blood pressure)surrogate

Heat stress enhances arterial baroreflex control of muscle sympathetic nerve activity through increased sensitivity of burst gating rather than burst area.

Cite This Study

Keller et al. (2006) studied this question.

synapsesocial.com/papers/6a70a95bce524a4339c460fd https://doi.org/10.1113/jphysiol.2006.108662

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Heat stress enhances arterial baroreflex control of muscle sympathetic nerve activity via increased sensitivity of burst gating, not burst area, in humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Heat stress enhances arterial baroreflex control of muscle sympathetic nerve activity via increased sensitivity of burst gating, not burst area, in humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider