Why the study?
Does oral dronedarone affect the circadian variation of RR and QT intervals in healthy subjects?
Population
Healthy subjects divided into 5 groups
Comparison
Oral dronedarone in a twice-daily regimen vs Placebo
Design
Other
Authors
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May guide ECG monitoring during dronedarone initiation; extends class III and sympatholytic characterization to healthy subjects.
Does oral dronedarone affect the circadian variation of RR and QT intervals in healthy subjects?
Dronedarone exhibits dose-dependent class III antiarrhythmic and sympatholytic effects by prolonging RR and QT intervals without altering circadian rhythms in healthy subjects.
Wadhani et al. (2006) studied this question.
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