Why the study?
Does sotalol improve survival compared to lignocaine in patients with out-of-hospital ventricular fibrillation refractory to multiple shocks?
Population
129 patients with out-of-hospital ventricular fibrillation refractory to ≥ 4 defibrillatory shocks, treated…
Comparison
Sotalol 100 mg i.v. bolus, followed by 2 min of… vs Lignocaine 100 mg i.v. bolus, followed by 2 min…
Design
RCT, randomized, double-blind
Follow-up
until hospital discharge
Authors
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Sotalol confers no survival benefit over lignocaine in refractory VF; confirms lack of efficacy and leaves open need for superior agents.
Does sotalol improve survival compared to lignocaine in patients with out-of-hospital ventricular fibrillation refractory to multiple shocks?
In out-of-hospital refractory ventricular fibrillation, sotalol did not improve survival to hospital admission or discharge compared to lignocaine.
Kovoor et al. (2005) studied this question.
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