Key result
Intravenous amiodarone increased survival to hospital admission compared with lidocaine for shock-resistant out-of-hospital ventricular fibrillation (22.8% vs 12.0%; OR 2.17; P=0.009).
Why the study?
Does intravenous amiodarone improve survival to hospital admission compared to intravenous lidocaine in patients with shock-resistant out-of-hospital ventricular fibrillation?
RCT (n=347)
double-blind
randomly assigned
Does intravenous amiodarone improve survival to hospital admission compared to intravenous lidocaine in patients with shock-resistant out-of-hospital ventricular fibrillation?
Odds Ratio: 2.17 (95% CI 1.21–3.83)
Absolute Event Rate: 22.8% vs 12%
p-value: p=0.009
Intravenous amiodarone significantly increases the rate of survival to hospital admission compared to lidocaine in patients with shock-resistant out-of-hospital ventricular fibrillation.
No takes yet. Share an insight, caveat, or question.
Favors amiodarone over lidocaine for shock-refractory VF; confirms benefit on survival to admission in out-of-hospital arrest.
Dorian et al. (2002) conducted an RCT in shock-resistant out-of-hospital ventricular fibrillation (n=347). Intravenous amiodarone vs. Intravenous lidocaine was evaluated on proportion of patients who survived to be admitted to the hospital (OR 2.17, 95% CI 1.21 to 3.83, p=0.009). Intravenous amiodarone increased survival to hospital admission compared with lidocaine for shock-resistant out-of-hospital ventricular fibrillation (22.8% vs 12.0%; OR 2.17; P=0.009).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: