Why the study?
Does intravenous amiodarone improve survival to hospital admission in patients with out-of-hospital cardiac arrest due to refractory ventricular fibrillation or pulseless ventricular tachycardia?
Population
504 patients with out-of-hospital cardiac arrest with ventricular fibrillation who had not been resuscitated…
Comparison
Amiodarone 300 mg intravenous vs Matching intravenous placebo
Design
RCT, Randomly assigned, Double-blind, placebo-controlled
Follow-up
Until hospital discharge
Authors
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Supports IV amiodarone in refractory VF/pVT arrest; confirms admission survival benefit and extends antiarrhythmic evidence in resuscitation.
Does intravenous amiodarone improve survival to hospital admission in patients with out-of-hospital cardiac arrest due to refractory ventricular fibrillation or pulseless ventricular tachycardia?
In patients with out-of-hospital cardiac arrest due to refractory ventricular arrhythmias, 300 mg of intravenous amiodarone significantly improves survival to hospital admission compared to placebo.
Kudenchuk et al. (1999) studied this question.
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