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This research aims to clone and characterize a new subtype of the amino acid transport system N identified in rat brain.

Cloning and functional characterization of a new subtype of the amino acid transport system N

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Randomized trial investigates a new subtype of amino acid transport in rat tissues, suggesting its diverse functions.

This research aims to clone and characterize a new subtype of the amino acid transport system N identified in rat brain.
Clone the SN2 subtype from rat brain tissue.
Analyze SN2 mRNA expression across various rat organs.
Test the functionality of SN2 in Xenopus laevis oocytes and mammalian cells.
Rat SN2 consists of 471 amino acids and shows 63% identity with SN1.
The transport mechanism is electrogenic and mediates Na(+)-dependent transport of several neutral amino acids.
Rat SN2 mRNA is most abundant in the liver and detectable in other tissues like the brain.

Nakanishi et al. (2001) studied this question.

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