August 31, 2016Frontiers in PhysiologyOpen Access

Recognition of Fibrotic Infarct Density by the Pattern of Local Systolic-Diastolic Myocardial Electrical Impedance

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Population

6 female domestic swine weighing 33 ± 2 kg with a 4-week old healed myocardial infarction induced by 150 min…

Comparison

Local measurement of phasic systolic-diastolic… vs Comparison between normal myocardium…

Design

Preclinical

Follow-up

4 weeks

Authors

GAGerard Amorós-FiguerasHospital de Sant Pau EJEsther JorgeUniversitat de Vic - Universitat Central de Catalunya TGTomás García-SánchezUniversitat Pompeu Fabra

Discussion

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Implication

Characterizes post-MI impedance shifts in pigs; leaves open human validation for tissue characterization or risk stratification.

Structured PICO

Population

6 female domestic swine (Landrace-Large White cross) weighing 33 ± 2 kg with a 4-week old healed myocardial infarction induced by 150 min of left anterior descending (LAD) coronary artery occlusion followed by reperfusion.

Intervention

Local measurement of phasic systolic-diastolic myocardial electrical impedance spectroscopy (1-1000 kHz) using an intramural 4-needle electrode probe.

Comparator

Comparison between normal myocardium (<10% fibrosis), heterogeneous scar (10-50% fibrosis), and dense scar (>50% fibrosis) within the same subjects.

Outcome

Correlation between local myocardial impedance (resistivity and phase angle) and the degree of local fibrosis.surrogate

Local measurement of phasic systolic-diastolic bioimpedance spectrum can detect differences in myocardial fibrosis in vivo, offering a potential future method to guide arrhythmia ablation.

Limitations

Measurements obtained with an intramural 4-needle electrode probe in an open-chest model
Thinning of the left ventricle in infarcted sites could affect the impedance spectrum due to proximity to blood volume

Cite This Study

Amorós-Figueras et al. (2016) studied this question.

synapsesocial.com/papers/6a70ab6887f921057127d2dd https://doi.org/10.3389/fphys.2016.00389

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Recognition of Fibrotic Infarct Density by the Pattern of Local Systolic-Diastolic Myocardial Electrical Impedance

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Recognition of Fibrotic Infarct Density by the Pattern of Local Systolic-Diastolic Myocardial Electrical Impedance

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider