What question did this study set out to answer?

To evaluate whether diphosphonates containing a P-C-P bond inhibit calcium phosphate crystallization in vitro and suppress pathological vascular calcification in vivo.

September 19, 1969Science

Diphosphonates Inhibit Formation of Calcium Phosphate Crystals in vitro and Pathological Calcification in vivo

View Full Paper

Ask AI

Bookmark

Authors

MFMarion D. FrancisMiami Valley Hospital RGR. GrahamUniversity of Oxford RRR.G.G. RussellNuffield Orthopaedic Centre

Discussion

Member takes

Implication

Experimental study demonstrates that oral diphosphonates prevent aortic calcification in vitamin D3-treated rats, indicating therapeutic potential against pathological mineral deposition.

Key Points

To evaluate whether diphosphonates containing a P-C-P bond inhibit calcium phosphate crystallization in vitro and suppress pathological vascular calcification in vivo.
Assessed two synthetic diphosphonates containing P-C-P bonds, CH3C(OH)(PO3HNa)2 and H2C(PO3HNa)2, for their ability to block calcium phosphate crystal formation in vitro.
Administered the diphosphonates orally to rats with pathological aortic calcification induced by excessive doses of vitamin D3.
Both tested diphosphonates markedly inhibited calcium phosphate crystallization in vitro.
Oral administration of both agents prevented aortic calcification in vitamin D3-treated rats, demonstrating functional efficacy comparable to P-O-P bond compounds via an oral route.

Cite This Study

Francis et al. (1969) studied this question.

synapsesocial.com/papers/6a70ab96f44fa9f079de5a20 https://doi.org/10.1126/science.165.3899.1264

View Full Paper

Ask AI

Bookmark

September 19, 1969Science

Diphosphonates Inhibit Formation of Calcium Phosphate Crystals in vitro and Pathological Calcification in vivo

View Full Paper

Ask AI

Bookmark

Authors

MFMarion D. FrancisMiami Valley Hospital RGR. GrahamUniversity of Oxford RRR.G.G. RussellNuffield Orthopaedic Centre

Discussion

Member takes

Implication

Experimental study demonstrates that oral diphosphonates prevent aortic calcification in vitamin D3-treated rats, indicating therapeutic potential against pathological mineral deposition.

Key Points

To evaluate whether diphosphonates containing a P-C-P bond inhibit calcium phosphate crystallization in vitro and suppress pathological vascular calcification in vivo.
Assessed two synthetic diphosphonates containing P-C-P bonds, CH3C(OH)(PO3HNa)2 and H2C(PO3HNa)2, for their ability to block calcium phosphate crystal formation in vitro.
Administered the diphosphonates orally to rats with pathological aortic calcification induced by excessive doses of vitamin D3.
Both tested diphosphonates markedly inhibited calcium phosphate crystallization in vitro.
Oral administration of both agents prevented aortic calcification in vitamin D3-treated rats, demonstrating functional efficacy comparable to P-O-P bond compounds via an oral route.

Cite This Study

Francis et al. (1969) studied this question.

synapsesocial.com/papers/6a70ab96f44fa9f079de5a20 https://doi.org/10.1126/science.165.3899.1264

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark