Why the study?
Does clopidogrel plus aspirin reduce new symptomatic or asymptomatic ischemic lesions on MRI in patients with acute ischemic stroke of presumed large artery atherosclerosis origin?
Population
358 patients with acute ischemic stroke of presumed large artery atherosclerosis origin within 48 hours of…
Comparison
Clopidogrel plus aspirin for 30 days vs Aspirin alone and matching placebo for 30 days
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
30 days
Authors
Loading...
No reduction in recurrent lesions with added clopidogrel; challenges presumed benefit and leaves open optimal antiplatelet strategy in large-artery stroke.
Does clopidogrel plus aspirin reduce new symptomatic or asymptomatic ischemic lesions on MRI in patients with acute ischemic stroke of presumed large artery atherosclerosis origin?
In patients with acute ischemic stroke caused by large artery atherosclerosis, adding clopidogrel to aspirin did not significantly reduce the incidence of new ischemic lesions on MRI at 30 days compared to aspirin alone.
Hong et al. (2016) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: