Key result
Same-day ozone exposure linked to ~2% higher stroke hospitalization risk per IQR in older adults.
Case-Control
Effect estimate: 1.9% risk increase per IQR increase (95% CI 0.01-3.8)
Background: Epidemiological studies have shown adverse short-term effects of air pollution on health including cardiovascular morbidity and mortality. However, air pollution-related stroke has received less attention. Methods: In this study, we performed a time-stratified case-crossover analysis to evaluate the relationships between stroke hospital admissions and O₃, among patients aged 65 years and older in Allegheny County, Pa., USA, between 1994 and 2000. We also examined whether the effects of air pollutants differed across strata defined by patient demographic characteristics and ambient temperature. Results: Exposures to O₃ on the current day increase the risk of total stroke hospitalization by 1.9% (95% CI: 0.01-3.8) per interquartile range increase in concentration. Furthermore, the results suggest that males were more sensitive to adverse health effects of O₃ on stroke hospitalization than females. Conclusion: These results suggest that O₃ has an adverse effect on stroke hospitalization. Specific patient subgroups, such as males, may be at increased risk.
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Xu et al. (2013) conducted a case-control in Stroke. Ozone (O3) exposure vs. Time-stratified control periods (per interquartile range increase in O3 concentration) was evaluated on Total stroke hospitalization (1.9% risk increase per IQR increase, 95% CI 0.01-3.8). Current-day ozone exposure increased total stroke hospitalization risk by 1.9% (95% CI: 0.01-3.8) per interquartile range concentration increase in adults aged ≥65 years.
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