Why the study?
Does pharmacological prophylaxis prevent postoperative venous thromboembolism in surgical patients?
Does pharmacological prophylaxis prevent postoperative venous thromboembolism in surgical patients?
This review highlights the optimal timing and duration of pharmacological prophylaxis for venous thromboembolism in high-risk surgical patients.
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May guide VTE prophylaxis timing and duration in high-risk surgery; leaves open need for prospective RCT confirmation.
This review article first deals with risk factors for developing postoperative venous thromboembolism. The various pharmacological prophylactic methods available today are summarized with focus on dominating method low molecular weight heparin and the two new ones, the Xa inhibitor fondaparinux and the IIa inhibitor ximelagatran, both approved in orthopaedic surgery. The optimal timing to start prophylaxis is between 2 hours before and 10 hours after surgery. Evidence is accumulating that some in risk groups prolonged prophylaxis is indicated, ie. elective hip surgery, probably hip fracture surgery and probably also patients operated on for abdominal/pelvic cancer.
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David Bergqvist (2003) studied this question.
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