Why the study?
Are small dense LDL levels elevated in patients with acute coronary syndrome compared to healthy controls, and do they change within 24 hours of symptom onset?
Are small dense LDL levels elevated in patients with acute coronary syndrome compared to healthy controls, and do they change within 24 hours of symptom onset?
Small dense LDL levels are elevated at baseline in patients with acute coronary syndrome compared to healthy controls but do not change significantly within the first 24 hours.
Elevated sdLDL marks ACS presentation without acute change; leaves open its role in risk stratification pending prospective data.
Low-density lipoprotein (LDL), especially small dense LDL (sdLDL), plays a role in atherogenesis. We compared baseline sdLDL levels between healthy controls and patients with acute coronary syndrome (ACS). Blood samples were taken from patients diagnosed with myocardial infarction ([MI] n = 104) and unstable angina ([UA] n = 100). Both sdLDL and high-sensitivity C-reactive protein (hsCRP) levels were determined on admission and in the next 24 hours after the onset of symptoms. Baseline concentration of sdLDL was significantly higher in patients presenting with ACS than controls (P < .05). In the 24 hours following ACS, the sdLDL levels decreased insignificantly in both groups of patients with ACS (P > .05). The changes in sdLDL values were not significantly different between MI and UA participants (P > .05). Patients with ACS have higher concentration of sdLDL compared with the controls.
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Emadzadeh et al. (2012) studied this question.
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