Key result
Low HDL-C in ACS is linked to ~269% higher rates of inhospital acute heart failure.
Why the study?
Although the association between serum lipids and acute coronary syndrome is established, more information was needed regarding the impact of HDL-C on inhospital outcomes and short-term prognosis in patients with ACS.
Does low HDL-C level worsen inhospital and short-term outcomes in patients with acute coronary syndrome?
Observational (n=50)
Does low HDL-C level worsen inhospital and short-term outcomes in patients with acute coronary syndrome?
Absolute Event Rate: 48% vs 13%
p-value: p=<0.05
Low HDL-C levels in patients with acute coronary syndrome are associated with significantly worse inhospital and 1-month clinical outcomes.
Background: Acute coronary syndrome (ACS) is a cardiac emergency and constitutes a major burden globally. Association between serum lipid and ACS is established many years ago. Our study tried to have more information about the impact of high-density lipoprotein cholesterol (HDL-C) on inhospital outcome and short-term prognosis of patients with ACS. Materials and Methods: The study was a prospective comparative study. Clinical and chemical and interventional evaluation was done in hospital settings. A total number of 50 patients were included in the study and divided into two groups. Patients with low HDL-C level were in Group I and patients with normal HDL-C were in Group II. Results: Group I populations had more inhospital complications than Group II represented in acute heart failure (48% vs. 13%), cardiogenic shock (40% vs. 6%), complex coronary lesions (57% vs. 20%), and prolonged hospital stay (54% vs. 20%). A statistical significance was found regarding these variables ( P < 0.05). Regarding the outcome after 1 month, it is observed that patients of Group I significantly experienced heart failure (59.38% vs. 21.43%) and worsening angina (62.5% vs. 28.57%) with a statistically significant difference. In contrast, there is no statistically significant difference regarding myocardial infarction, new cerebrovascular events, shock, and mortality. Conclusion: The study showed a strong association of HDL-C level with inhospital adverse events of ACS patients in addition to short-term adverse events. Complications of ACS were more in patients with low HDL-C level.
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Elkholy et al. (2021) conducted an observational in Acute coronary syndrome (n=50). Low HDL-C vs. Normal HDL-C was evaluated on Inhospital acute heart failure (p=<0.05). Low HDL-C in ACS patients was associated with significantly higher rates of inhospital acute heart failure (48% vs. 13%, P<0.05) and cardiogenic shock (40% vs. 6%) compared to normal HDL-C.
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