Study of High Density Lipoprotein Cholesterol among Patients with Acute Coronary Syndrome in Sohag niversity Hospital

Objective: To estimate the prevalence, and impact of high-density lipoprotein cholesterol (HDL-C) on in-hospital outcomes among acute coronary syndrome (ACS) patients in Sohag University Hospital. Methods: Data were collected prospectively from 273 consecutive patients admitted with a diagnosis of ACS. A low HDL-C was defined as a level <40 mg/dL (1.0 mmol/L) for males and <50 mg/dL (1.3 mmol/L) for females and satisfactory HDL-C is defined as a level ≥40mg/dl for males and ≥50mg/dl for females. Results: The overall mean age of the study patients was 58.9_+11.3 years and majority was males (51.4%). The overall prevalence of low HDL-C was 73.3% and satisfactory HDL-C was 26.7%. During in-hospital stay and at discharge, the majority were on statin therapy (83.2%) while 7.7% were on fibrates. Low HDL-C patients were associated with higher in-hospital mortality than satisfactory HDL-C patients (12% vs. 11%; p=0.012) and higher CHF (18% vs.5.5%; p=0.01). Conclusion: ACS patients in Sohag governorate in upper Egypt have a high prevalence of low HDL-C. Insignificantly higher in-hospital mortality and CHF were associated with low HDL-C in women but not in men.